Acrolein-stressed threshold adaptation alters the molecular and metabolic bases of an engineered Saccharomyces cerevisiae to improve glutathione production

Acrolein (Acr) was used as a selection agent to improve the glutathione (GSH) overproduction of the prototrophic strain W303-1b/FGP(PT). After two rounds of adaptive laboratory evolution (ALE), an unexpected result was obtained wherein identical GSH production was observed in the selected isolates....

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Detalles Bibliográficos
Autores principales: Zhou, Wenlong, Yang, Yan, Tang, Liang, Cheng, Kai, Li, Changkun, Wang, Huimin, Liu, Minzhi, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852114/
https://www.ncbi.nlm.nih.gov/pubmed/29540749
http://dx.doi.org/10.1038/s41598-018-22836-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852114/
https://www.ncbi.nlm.nih.gov/pubmed/29540749
http://dx.doi.org/10.1038/s41598-018-22836-2

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