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Structure and function of the Nppa–Nppb cluster locus during heart development and disease

Atrial natriuretic factor and brain natriuretic peptide are two important biomarkers in clinical cardiology. These two natriuretic peptide hormones are encoded by the paralogous genes Nppa and Nppb, which are evolutionary conserved. Both genes are predominantly expressed by the heart muscle during t...

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Detalles Bibliográficos
Autores principales: Man, Joyce, Barnett, Phil, Christoffels, Vincent M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852170/
https://www.ncbi.nlm.nih.gov/pubmed/29302701
http://dx.doi.org/10.1007/s00018-017-2737-0
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author Man, Joyce
Barnett, Phil
Christoffels, Vincent M.
author_facet Man, Joyce
Barnett, Phil
Christoffels, Vincent M.
author_sort Man, Joyce
collection PubMed
description Atrial natriuretic factor and brain natriuretic peptide are two important biomarkers in clinical cardiology. These two natriuretic peptide hormones are encoded by the paralogous genes Nppa and Nppb, which are evolutionary conserved. Both genes are predominantly expressed by the heart muscle during the embryonic and fetal stages, and in particular Nppa expression is strongly reduced in the ventricles after birth. Upon cardiac stress, Nppa and Nppb are strongly upregulated in the ventricular myocardium. Much is known about the molecular and physiological ques inducing Nppa and Nppb expression; however, the transcriptional regulatory mechanisms of the Nppa–Nppb cluster in vivo has proven to be quite complex and is not well understood. In this review, we will provide recent insights into the dynamic and complex regulation of Nppa and Nppb during heart development and hypertrophy, and the association of this gene cluster with the cardiomyocyte-intrinsic program of heart regeneration.
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spelling pubmed-58521702018-03-21 Structure and function of the Nppa–Nppb cluster locus during heart development and disease Man, Joyce Barnett, Phil Christoffels, Vincent M. Cell Mol Life Sci Review Atrial natriuretic factor and brain natriuretic peptide are two important biomarkers in clinical cardiology. These two natriuretic peptide hormones are encoded by the paralogous genes Nppa and Nppb, which are evolutionary conserved. Both genes are predominantly expressed by the heart muscle during the embryonic and fetal stages, and in particular Nppa expression is strongly reduced in the ventricles after birth. Upon cardiac stress, Nppa and Nppb are strongly upregulated in the ventricular myocardium. Much is known about the molecular and physiological ques inducing Nppa and Nppb expression; however, the transcriptional regulatory mechanisms of the Nppa–Nppb cluster in vivo has proven to be quite complex and is not well understood. In this review, we will provide recent insights into the dynamic and complex regulation of Nppa and Nppb during heart development and hypertrophy, and the association of this gene cluster with the cardiomyocyte-intrinsic program of heart regeneration. Springer International Publishing 2018-01-04 2018 /pmc/articles/PMC5852170/ /pubmed/29302701 http://dx.doi.org/10.1007/s00018-017-2737-0 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Man, Joyce
Barnett, Phil
Christoffels, Vincent M.
Structure and function of the Nppa–Nppb cluster locus during heart development and disease
title Structure and function of the Nppa–Nppb cluster locus during heart development and disease
title_full Structure and function of the Nppa–Nppb cluster locus during heart development and disease
title_fullStr Structure and function of the Nppa–Nppb cluster locus during heart development and disease
title_full_unstemmed Structure and function of the Nppa–Nppb cluster locus during heart development and disease
title_short Structure and function of the Nppa–Nppb cluster locus during heart development and disease
title_sort structure and function of the nppa–nppb cluster locus during heart development and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852170/
https://www.ncbi.nlm.nih.gov/pubmed/29302701
http://dx.doi.org/10.1007/s00018-017-2737-0
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