Plastin 3 Promotes Motor Neuron Axonal Growth and Extends Survival in a Mouse Model of Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a devastating childhood motor neuron disease. SMA is caused by mutations in the survival motor neuron gene (SMN1), leading to reduced levels of SMN protein in the CNS. The actin-binding protein plastin 3 (PLS3) has been reported as a modifier for SMA, making it a pot...

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Detalles Bibliográficos
Autores principales: Alrafiah, Aziza, Karyka, Evangelia, Coldicott, Ian, Iremonger, Kayleigh, Lewis, Katherin E., Ning, Ke, Azzouz, Mimoun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852384/
https://www.ncbi.nlm.nih.gov/pubmed/29552580
http://dx.doi.org/10.1016/j.omtm.2018.01.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852384/
https://www.ncbi.nlm.nih.gov/pubmed/29552580
http://dx.doi.org/10.1016/j.omtm.2018.01.007

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