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Regional acidosis locally inhibits but remotely stimulates Ca(2+) waves in ventricular myocytes
AIMS: Spontaneous Ca(2+) waves in cardiomyocytes are potentially arrhythmogenic. A powerful controller of Ca(2+) waves is the cytoplasmic H(+) concentration ([H(+)](i)), which fluctuates spatially and temporally in conditions such as myocardial ischaemia/reperfusion. H(+)-control of Ca(2+) waves is...
Autores principales: | Ford, Kerrie L., Moorhouse, Emma L., Bortolozzi, Mario, Richards, Mark A., Swietach, Pawel, Vaughan-Jones, Richard D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852542/ https://www.ncbi.nlm.nih.gov/pubmed/28339694 http://dx.doi.org/10.1093/cvr/cvx033 |
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