Characterization of TTN Novex Splicing Variants across Species and the Role of RBM20 in Novex-Specific Exon Splicing

Titin (TTN) is a major disease-causing gene in cardiac muscle. Titin (TTN) contains 363 exons in human encoding various sizes of TTN protein due to alternative splicing regulated mainly by RNA binding motif 20 (RBM20). Three isoforms of TTN protein are produced by mutually exclusive exons 45 (Novex...

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Detalles Bibliográficos
Autores principales: Chen, Zhilong, Song, Jiangping, Chen, Liang, Zhu, Chaoqun, Cai, Hanfang, Sun, Mingming, Stern, Allysa, Mozdziak, Paul, Ge, Ying, Means, Warrie J., Guo, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852582/
https://www.ncbi.nlm.nih.gov/pubmed/29438341
http://dx.doi.org/10.3390/genes9020086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852582/
https://www.ncbi.nlm.nih.gov/pubmed/29438341
http://dx.doi.org/10.3390/genes9020086

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