Cargando…
PPARγ Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3K/AKT and cGMP/PKG Signaling
BACKGROUND AND AIMS: Accumulating evidence reveals that PPARγ plays a unique role in the regulation of hepatic fibrosis and hepatic stellate cells (HSCs) activation. This study was aimed at investigating the role of PPARγ in hypoxia-induced hepatic fibrogenesis and its possible mechanism. METHODS: R...
Autores principales: | Zhang, Qinghui, Xiang, Shihao, Liu, Qingqian, Gu, Tao, Yao, Yongliang, Lu, Xiaojie |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852857/ https://www.ncbi.nlm.nih.gov/pubmed/29686697 http://dx.doi.org/10.1155/2018/6970407 |
Ejemplares similares
-
The role of cGMP and PKG in cardioprotection
por: Downey, James M, et al.
Publicado: (2009) -
Role of cGMP/PKG in fat tissue
por: Pfeifer, Alexander
Publicado: (2011) -
PKC and AKT Modulate cGMP/PKG Signaling Pathway on Platelet Aggregation in Experimental Sepsis
por: Lopes-Pires, M. Elisa, et al.
Publicado: (2015) -
Structures of human PKG reveal cGMP-selectived activation mechanisms
por: Huang, Gilbert Y, et al.
Publicado: (2013) -
cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway
por: Park, Min, et al.
Publicado: (2018)