Cargando…
How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties
BACKGROUND: Much of the structure-based mechanistic understandings of the function of SLC6A neurotransmitter transporters emerged from the study of their bacterial LeuT-fold homologs. It has become evident, however, that structural differences such as the long N- and C-termini of the eukaryotic neur...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852957/ https://www.ncbi.nlm.nih.gov/pubmed/29540172 http://dx.doi.org/10.1186/s12915-018-0495-6 |