α-catenin SUMOylation increases IκBα stability and inhibits breast cancer progression

α-catenin has been demonstrated to suppress several different types of cancers. Here we demonstrate that α-catenin is modified by SUMO protein, which covalently binds α-catenin at the carboxy terminus at lysine 870. Substitution of lysine 870 with arginine completely abolishes α-catenin SUMOylation....

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Detalles Bibliográficos
Autores principales: Chen, Huan, Xu, Zhaowei, Li, Xiahui, Yang, Yangyang, Li, Bowen, Li, Yanan, Xia, Kangkai, Wang, Jian, Li, Shujing, Wang, Miao, Wu, Huijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852976/
https://www.ncbi.nlm.nih.gov/pubmed/29540699
http://dx.doi.org/10.1038/s41389-018-0037-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852976/
https://www.ncbi.nlm.nih.gov/pubmed/29540699
http://dx.doi.org/10.1038/s41389-018-0037-7

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