An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation

BACKGROUND: NSC260594, a quinolinium derivative from the NCI diversity set II compound library, was previously identified in a target-based assay as an inhibitor of the interaction between the HIV-1 (ψ) stem-loop 3 (SL3) RNA and Gag. This compound was shown to exhibit potent antiviral activity. Here...

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Detalles Bibliográficos
Autores principales: Ingemarsdotter, Carin K., Zeng, Jingwei, Long, Ziqi, Lever, Andrew M.L., Kenyon, Julia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853050/
https://www.ncbi.nlm.nih.gov/pubmed/29540207
http://dx.doi.org/10.1186/s12977-018-0407-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853050/
https://www.ncbi.nlm.nih.gov/pubmed/29540207
http://dx.doi.org/10.1186/s12977-018-0407-4

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