High-fat diet modifies expression of hepatic cellular senescence gene p16(INK4a) through chromatin modifications in adult male rats

BACKGROUND: Liver is the crucial organ as a hub for metabolic reactions. p16(INK4a) is a well-established cyclin-dependent kinase (CDK) inhibitor that plays important role in the molecular pathways of senescence, which lead to irreversible cell cycle arrest with secretion of proinflammatory cytokine...

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Detalles Bibliográficos
Autores principales: Zhang, Xiyuan, Xu, Guanying Bianca, Zhou, Dan, Pan, Yuan-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853101/
https://www.ncbi.nlm.nih.gov/pubmed/29564021
http://dx.doi.org/10.1186/s12263-018-0595-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853101/
https://www.ncbi.nlm.nih.gov/pubmed/29564021
http://dx.doi.org/10.1186/s12263-018-0595-5

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