Cargando…
Glutaminase 1 regulates the release of extracellular vesicles during neuroinflammation through key metabolic intermediate alpha-ketoglutarate
BACKGROUND: Extracellular vesicles (EVs) are important in the intercellular communication of the central nervous system, and their release is increased during neuroinflammation. Our previous data demonstrated an increased release of EVs during HIV-1 infection and immune activation in glial cells. Ho...
Autores principales: | Wu, Beiqing, Liu, Jianhui, Zhao, Runze, Li, Yuju, Peer, Justin, Braun, Alexander L., Zhao, Lixia, Wang, Yi, Tong, Zenghan, Huang, Yunlong, Zheng, Jialin C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853116/ https://www.ncbi.nlm.nih.gov/pubmed/29540215 http://dx.doi.org/10.1186/s12974-018-1120-x |
Ejemplares similares
-
Glutaminase-containing microvesicles from HIV-1-infected macrophages and immune-activated microglia induce neurotoxicity
por: Wu, Beiqing, et al.
Publicado: (2015) -
Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration
por: Li, Yuju, et al.
Publicado: (2017) -
TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase
por: Wang, Kaizhe, et al.
Publicado: (2017) -
Zika virus propagation and release in human fetal astrocytes can be suppressed by neutral sphingomyelinase-2 inhibitor GW4869
por: Huang, Yunlong, et al.
Publicado: (2018) -
STAT1 Regulates Human Glutaminase 1 Promoter Activity through Multiple Binding Sites in HIV-1 Infected Macrophages
por: Zhao, Lixia, et al.
Publicado: (2013)