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Antiviral Effect of Ribavirin against HCV Associated with Increased Frequency of G-to-A and C-to-U Transitions in Infectious Cell Culture Model

Ribavirin (RBV) is a broad-spectrum antiviral active against a wide range of RNA viruses. Despite having been used for decades in the treatment of chronic hepatitis C virus (HCV) infection, the precise mechanism of action of RBV is unknown. In other viruses, it inhibits propagation by increasing the...

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Detalles Bibliográficos
Autores principales: Galli, Andrea, Mens, Helene, Gottwein, Judith M., Gerstoft, Jan, Bukh, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854589/
https://www.ncbi.nlm.nih.gov/pubmed/29545599
http://dx.doi.org/10.1038/s41598-018-22620-2