Rare variants in drug target genes contributing to complex diseases, phenome-wide

The DrugBank database consists of ~800 genes that are well characterized drug targets. This list of genes is a useful resource for association testing. For example, loss of function (LOF) genetic variation has the potential to mimic the effect of drugs, and high impact variation in these genes can i...

Descripción completa

Detalles Bibliográficos
Autores principales: Verma, Shefali Setia, Josyula, Navya, Verma, Anurag, Zhang, Xinyuan, Veturi, Yogasudha, Dewey, Frederick E., Hartzel, Dustin N., Lavage, Daniel R., Leader, Joe, Ritchie, Marylyn D., Pendergrass, Sarah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854600/
https://www.ncbi.nlm.nih.gov/pubmed/29545597
http://dx.doi.org/10.1038/s41598-018-22834-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854600/
https://www.ncbi.nlm.nih.gov/pubmed/29545597
http://dx.doi.org/10.1038/s41598-018-22834-4

Ejemplares similares