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How RNA transcripts coordinate DNA recombination and repair

Genetic studies in yeast indicate that RNA transcripts facilitate homology-directed DNA repair in a manner that is dependent on RAD52. The molecular basis for so-called RNA−DNA repair, however, remains unknown. Using reconstitution assays, we demonstrate that RAD52 directly cooperates with RNA as a...

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Detalles Bibliográficos
Autores principales: McDevitt, Shane, Rusanov, Timur, Kent, Tatiana, Chandramouly, Gurushankar, Pomerantz, Richard T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854605/
https://www.ncbi.nlm.nih.gov/pubmed/29545568
http://dx.doi.org/10.1038/s41467-018-03483-7