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Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis
Regulatory T (Treg) cells contribute to the anti-inflammatory response during atherogenesis. Here we show that during atherogenesis Treg cells lose Foxp3 expression and their immunosuppressive function, leading to the conversion of a fraction of these cells into T follicular helper (Tfh) cells. We s...
Autores principales: | Gaddis, Dalia E., Padgett, Lindsey E., Wu, Runpei, McSkimming, Chantel, Romines, Veronica, Taylor, Angela M., McNamara, Coleen A., Kronenberg, Mitchell, Crotty, Shane, Thomas, Michael J., Sorci-Thomas, Mary G., Hedrick, Catherine C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854619/ https://www.ncbi.nlm.nih.gov/pubmed/29545616 http://dx.doi.org/10.1038/s41467-018-03493-5 |
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