Analysis of mutations in pncA reveals non-overlapping patterns among various lineages of Mycobacterium tuberculosis

Pyrazinamide (PZA) is an important first-line anti-tuberculosis drug, resistance to which occurs primarily due to mutations in pncA (Rv2043c) that encodes the pyrazinamidase enzyme responsible for conversion of pro-drug PZA into its active form. Previous studies have reported numerous resistance-con...

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Detalles Bibliográficos
Autores principales: Baddam, Ramani, Kumar, Narender, Wieler, Lothar H., Lankapalli, Aditya Kumar, Ahmed, Niyaz, Peacock, Sharon J., Semmler, Torsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854631/
https://www.ncbi.nlm.nih.gov/pubmed/29545614
http://dx.doi.org/10.1038/s41598-018-22883-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854631/
https://www.ncbi.nlm.nih.gov/pubmed/29545614
http://dx.doi.org/10.1038/s41598-018-22883-9

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