Cargando…

Mitochondrial Molecular Abnormalities Revealed by Proteomic Analysis of Hippocampal Organelles of Mice Triple Transgenic for Alzheimer Disease

Mitochondrial dysfunction is implicated in the pathogenesis of Alzheimer’s disease (AD). However, the precise mitochondrial molecular deficits in AD remain poorly understood. Mitochondrial and nuclear proteomic analysis in mature male triple transgenic AD mice (PS1M146V/APPSwe/TauP301L) by two-dimen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Haitao, Lin, Xuemei, Wang, Dian, Zhang, Zaijun, Guo, Yi, Ren, Xiaohu, Xu, Benhong, Yuan, Jianhui, Liu, Jianjun, Spencer, Peter S., Wang, Jian-Zhi, Yang, Xifei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854685/ https://www.ncbi.nlm.nih.gov/pubmed/29593495 http://dx.doi.org/10.3389/fnmol.2018.00074

Ejemplares similares

Ginsenoside Rg1 Ameliorates Behavioral Abnormalities and Modulates the Hippocampal Proteomic Change in Triple Transgenic Mice of Alzheimer's Disease
por: Nie, Lulin, et al.
Publicado: (2017)

Memantine Improves Cognitive Function and Alters Hippocampal and Cortical Proteome in Triple Transgenic Mouse Model of Alzheimer's Disease
por: Zhou, Xinhua, et al.
Publicado: (2019)

TRPC1 Deletion Causes Striatal Neuronal Cell Apoptosis and Proteomic Alterations in Mice
por: Wang, Dian, et al.
Publicado: (2018)

Ultrasound with microbubbles improves memory, ameliorates pathology and modulates hippocampal proteomic changes in a triple transgenic mouse model of Alzheimer's disease
por: Shen, Yuanyuan, et al.
Publicado: (2020)

Tetramethylpyrazine Improves Cognitive Impairment and Modifies the Hippocampal Proteome in Two Mouse Models of Alzheimer's Disease
por: Huang, Xianfeng, et al.
Publicado: (2021)

Proteomic analysis reveals the potential neuroprotective effects of tetramethylpyrazine dimer in neuro2a/APPswe cells
por: Lin, Xiaoyi, et al.
Publicado: (2019)

Dauricine Attenuates Spatial Memory Impairment and Alzheimer-Like Pathologies by Enhancing Mitochondrial Function in a Mouse Model of Alzheimer's Disease
por: Chen, Chongyang, et al.
Publicado: (2021)

The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-Like Pathological Changes In Vitro
por: Liu, Pan, et al.
Publicado: (2018)

Proteomic Profile of Mouse Brain Aging Contributions to Mitochondrial Dysfunction, DNA Oxidative Damage, Loss of Neurotrophic Factor, and Synaptic and Ribosomal Proteins
por: Li, Yingchao, et al.
Publicado: (2020)

Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer’s disease mouse model and proteomics analysis
por: Zhou, Xinhua, et al.
Publicado: (2023)

SOD1 is a Possible Predictor of COVID-19 Progression as Revealed by Plasma Proteomics
por: Xu, Benhong, et al.
Publicado: (2021)

Compensatory remodeling of a septo-hippocampal GABAergic network in the triple transgenic Alzheimer’s mouse model
por: Wander, Connor M, et al.
Publicado: (2023)

Organelle and Cellular Abnormalities Associated with Hippocampal Heterotopia in Neonatal Doublecortin Knockout Mice
por: Khalaf-Nazzal, Reham, et al.
Publicado: (2013)

Redox Proteomic Profiling of Specifically Carbonylated Proteins in the Serum of Triple Transgenic Alzheimer’s Disease Mice
por: Shen, Liming, et al.
Publicado: (2016)

Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer’s disease mouse model
por: Lin, Xiaoxiao, et al.
Publicado: (2022)

The Prenylflavonoid Xanthohumol Reduces Alzheimer-Like Changes and Modulates Multiple Pathogenic Molecular Pathways in the Neuro2a/APP(swe) Cell Model of AD
por: Huang, Xianfeng, et al.
Publicado: (2018)

Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease
por: Zhou, Yujuan, et al.
Publicado: (2023)

Increased hippocampal CA1 density of serotonergic terminals in a triple transgenic mouse model of Alzheimer's disease: an ultrastructural study
por: Noristani, H N, et al.
Publicado: (2011)

Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer’s Disease
por: Carvalho da Silva, António M., et al.
Publicado: (2022)

Sex differences in hippocampal β-amyloid accumulation in the triple-transgenic mouse model of Alzheimer’s disease and the potential role of local estrogens
por: Hu, Yu-Ting, et al.
Publicado: (2023)

Dendritic complexity change in the triple transgenic mouse model of Alzheimer’s disease
por: Zhang, Yu, et al.
Publicado: (2020)

Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer’s mouse model are associated with hippocampal synaptic deficits in an age-dependent manner
por: Joseph, Donald J., et al.
Publicado: (2019)

Erratum: Sex differences in hippocampal β-amyloid accumulation in the triple-transgenic mouse model of Alzheimer's disease and the potential role of local estrogens
Publicado: (2023)

Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer’s Disease
por: Unger, M. S., et al.
Publicado: (2016)

Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?
por: Olabarria, Markel, et al.
Publicado: (2011)

Sex-Dependent Altered Expression of Cannabinoid Signaling in Hippocampal Astrocytes of the Triple Transgenic Mouse Model of Alzheimer’s Disease: Implications for Controlling Astroglial Activity
por: Pacheco-Sánchez, Beatriz, et al.
Publicado: (2023)

Classification of Alzheimer’s Disease Based on Abnormal Hippocampal Functional Connectivity and Machine Learning
por: Zhu, Qixiao, et al.
Publicado: (2022)

Urinary nicotine metabolites are associated with cognitive impairment among the elderly in southern China
por: Huang, Chao, et al.
Publicado: (2023)

Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer’s disease
por: St-Amour, Isabelle, et al.
Publicado: (2019)

Proteomics of a fuzzy organelle: interphase chromatin
por: Kustatscher, Georg, et al.
Publicado: (2014)

Proteomics of Secretory and Endocytic Organelles in Giardia lamblia
por: Wampfler, Petra B., et al.
Publicado: (2014)

Alterations of brain and cerebellar proteomes linked to Aβ and tau pathology in a female triple-transgenic murine model of Alzheimer's disease
por: Ciavardelli, D, et al.
Publicado: (2010)

Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model
por: Paula, Pérez-Corredor, et al.
Publicado: (2019)

Valproic Acid Stimulates Hippocampal Neurogenesis via Activating the Wnt/β-Catenin Signaling Pathway in the APP/PS1/Nestin-GFP Triple Transgenic Mouse Model of Alzheimer’s Disease
por: Zeng, Qinghua, et al.
Publicado: (2019)

Clinical characteristics of COVID-19 patients with abnormal liver tests
por: Chen, Peng, et al.
Publicado: (2020)

New Insights Into the Role of Aberrant Hippocampal Neurogenesis in Epilepsy
por: Chen, Peng, et al.
Publicado: (2021)

Proteomic Identification of Bombyx mori Organelles Using the Engineered Ascorbate Peroxidase APEX and Development of Silkworm Organelle Proteome Database (SilkOrganPDB)
por: Li, Tian, et al.
Publicado: (2021)

Multiple Events Lead to Dendritic Spine Loss in Triple Transgenic Alzheimer's Disease Mice
por: Bittner, Tobias, et al.
Publicado: (2010)

Staging of Alzheimer's Pathology in Triple Transgenic Mice: A Light and Electron Microscopic Analysis
por: Oh, Kwang-Jin, et al.
Publicado: (2010)

Impaired Satiation and Increased Feeding Behaviour in the Triple-Transgenic Alzheimer's Disease Mouse Model
por: Adebakin, Adedolapo, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_4n86mcufqu20a8t3v61kfolol3