An acute functional screen identifies an effective antibody targeting amyloid-β oligomers based on calcium imaging

Soluble amyloid β oligomers (AβOs) are widely recognized neurotoxins that trigger aberrant signaling in specific subsets of neurons, leading to accumulated neuronal damage and memory disorders in Alzheimer’s disease (AD). One of the profound downstream consequences of AβO-triggered events is dysregu...

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Detalles Bibliográficos
Autores principales: Wang, Xueying, Kastanenka, Ksenia V., Arbel-Ornath, Michal, Commins, Caitlin, Kuzuya, Akira, Lariviere, Amanda J., Krafft, Grant A., Hefti, Franz, Jerecic, Jasna, Bacskai, Brian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854710/
https://www.ncbi.nlm.nih.gov/pubmed/29545579
http://dx.doi.org/10.1038/s41598-018-22979-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854710/
https://www.ncbi.nlm.nih.gov/pubmed/29545579
http://dx.doi.org/10.1038/s41598-018-22979-2

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