Cargando…
Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant
A key antioxidant pathway, the Keap1-Nrf2 system, is regulated by p62/Sqstm1 via multiple mechanisms, including gene expression, posttranslational modifications (such as ubiquitination and phosphorylation), and autophagic degradation of p62/Sqstm1 and Keap1. Here we demonstrate a novel mode of regul...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854834/ https://www.ncbi.nlm.nih.gov/pubmed/29339380 http://dx.doi.org/10.1128/MCB.00642-17 |