Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant

A key antioxidant pathway, the Keap1-Nrf2 system, is regulated by p62/Sqstm1 via multiple mechanisms, including gene expression, posttranslational modifications (such as ubiquitination and phosphorylation), and autophagic degradation of p62/Sqstm1 and Keap1. Here we demonstrate a novel mode of regul...

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Detalles Bibliográficos
Autores principales: Kageyama, Shun, Saito, Tetsuya, Obata, Miki, Koide, Ryo-hei, Ichimura, Yoshinobu, Komatsu, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854834/
https://www.ncbi.nlm.nih.gov/pubmed/29339380
http://dx.doi.org/10.1128/MCB.00642-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854834/
https://www.ncbi.nlm.nih.gov/pubmed/29339380
http://dx.doi.org/10.1128/MCB.00642-17

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