Incorporation of Immune Checkpoint Blockade into Chimeric Antigen Receptor T Cells (CAR-Ts): Combination or Built-In CAR-T

Chimeric antigen receptor (CAR) T cell therapy represents the first U.S. Food and Drug Administration approved gene therapy and these engineered cells function with unprecedented efficacy in the treatment of refractory CD19 positive hematologic malignancies. CAR translation to solid tumors is also b...

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Detalles Bibliográficos
Autores principales: Yoon, Dok Hyun, Osborn, Mark J., Tolar, Jakub, Kim, Chong Jai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855562/
https://www.ncbi.nlm.nih.gov/pubmed/29364163
http://dx.doi.org/10.3390/ijms19020340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855562/
https://www.ncbi.nlm.nih.gov/pubmed/29364163
http://dx.doi.org/10.3390/ijms19020340

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