Poly-N-Acetyllactosamine Neo-Glycoproteins as Nanomolar Ligands of Human Galectin-3: Binding Kinetics and Modeling

Galectin-3 (Gal-3) is recognized as a prognostic marker in several cancer types. Its involvement in tumor development and proliferation makes this lectin a promising target for early cancer diagnosis and anti-cancer therapies. Gal-3 recognizes poly-N-acetyllactosamine (LacNAc)-based carbohydrate mot...

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Detalles Bibliográficos
Autores principales: Bumba, Ladislav, Laaf, Dominic, Spiwok, Vojtěch, Elling, Lothar, Křen, Vladimír, Bojarová, Pavla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855594/
https://www.ncbi.nlm.nih.gov/pubmed/29373511
http://dx.doi.org/10.3390/ijms19020372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855594/
https://www.ncbi.nlm.nih.gov/pubmed/29373511
http://dx.doi.org/10.3390/ijms19020372

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