Resistance to the Antiproliferative In Vitro Effect of PI3K-Akt-mTOR Inhibition in Primary Human Acute Myeloid Leukemia Cells Is Associated with Altered Cell Metabolism

Constitutive signaling through the phosphatidylinositol-3-kinase-Akt-mechanistic target of rapamycin (PI3K-Akt-mTOR) pathway is present in acute myeloid leukemia (AML) cells. However, AML is a heterogeneous disease, and we therefore investigated possible associations between cellular metabolism and...

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Detalles Bibliográficos
Autores principales: Nepstad, Ina, Reikvam, Håkon, Brenner, Annette K., Bruserud, Øystein, Hatfield, Kimberley J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855604/
https://www.ncbi.nlm.nih.gov/pubmed/29382066
http://dx.doi.org/10.3390/ijms19020382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855604/
https://www.ncbi.nlm.nih.gov/pubmed/29382066
http://dx.doi.org/10.3390/ijms19020382

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