Inhibition of GLO1 in Glioblastoma Multiforme Increases DNA-AGEs, Stimulates RAGE Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models

Cancers that exhibit the Warburg effect may elevate expression of glyoxylase 1 (GLO1) to detoxify the toxic glycolytic byproduct methylglyoxal (MG) and inhibit the formation of pro-apoptotic advanced glycation endproducts (AGEs). Inhibition of GLO1 in cancers that up-regulate glycolysis has been pro...

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Detalles Bibliográficos
Autores principales: Jandial, Rahul, Neman, Josh, Lim, Punnajit P., Tamae, Daniel, Kowolik, Claudia M., Wuenschell, Gerald E., Shuck, Sarah C., Ciminera, Alexandra K., De Jesus, Luis R., Ouyang, Ching, Chen, Mike Y., Termini, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855628/
https://www.ncbi.nlm.nih.gov/pubmed/29385725
http://dx.doi.org/10.3390/ijms19020406

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855628/
https://www.ncbi.nlm.nih.gov/pubmed/29385725
http://dx.doi.org/10.3390/ijms19020406

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