Inhibition of Phosphodiesterase 4 by FCPR03 Alleviates Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of p38 and JNK Signaling Pathways

Inflammatory responses induced by peripheral administration of lipopolysaccharide (LPS) triggers depressive-like behavioral syndrome in rodents. Inhibition of phosphodiesterase 4 (PDE4) produces a robust anti-inflammatory effect in inflammatory cells. Unfortunately, archetypal PDE4 inhibitors cause...

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Detalles Bibliográficos
Autores principales: Yu, Hui, Zou, Zhengqiang, Zhang, Xiaolin, Peng, Wanli, Chen, Chen, Ye, Yicheng, Xu, Jiangping, Wang, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855735/
https://www.ncbi.nlm.nih.gov/pubmed/29419799
http://dx.doi.org/10.3390/ijms19020513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855735/
https://www.ncbi.nlm.nih.gov/pubmed/29419799
http://dx.doi.org/10.3390/ijms19020513

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