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Inhibition of Phosphodiesterase 4 by FCPR03 Alleviates Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of p38 and JNK Signaling Pathways

Inflammatory responses induced by peripheral administration of lipopolysaccharide (LPS) triggers depressive-like behavioral syndrome in rodents. Inhibition of phosphodiesterase 4 (PDE4) produces a robust anti-inflammatory effect in inflammatory cells. Unfortunately, archetypal PDE4 inhibitors cause...

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Detalles Bibliográficos
Autores principales:	Yu, Hui, Zou, Zhengqiang, Zhang, Xiaolin, Peng, Wanli, Chen, Chen, Ye, Yicheng, Xu, Jiangping, Wang, Haitao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855735/ https://www.ncbi.nlm.nih.gov/pubmed/29419799 http://dx.doi.org/10.3390/ijms19020513

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