Hypoxia Activates Src and Promotes Endocytosis Which Decreases MMP-2 Activity and Aggravates Renal Interstitial Fibrosis

The aggravation of renal interstitial fibrosis in the advanced-stage of chronic kidney disease is related to decreased matrix metalloproteinase-2 (MMP-2) activity, which is induced by hypoxia in the kidney; however, the specific mechanism remains unclear. We previously demonstrated that inhibition o...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Zhengyuan, Liu, Lei, Wang, Zhi, Cai, Yingying, Xu, Qing, Chen, Pingsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855803/
https://www.ncbi.nlm.nih.gov/pubmed/29462885
http://dx.doi.org/10.3390/ijms19020581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855803/
https://www.ncbi.nlm.nih.gov/pubmed/29462885
http://dx.doi.org/10.3390/ijms19020581

Ejemplares similares