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Sinus Bradycardia in Carriers of the SCN5A-1795insD Mutation: Unraveling the Mechanism through Computer Simulations
The SCN5A gene encodes the pore-forming α-subunit of the ion channel that carries the cardiac fast sodium current (I(Na)). The 1795insD mutation in SCN5A causes sinus bradycardia, with a mean heart rate of 70 beats/min in mutation carriers vs. 77 beats/min in non-carriers from the same family (lowes...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855856/ https://www.ncbi.nlm.nih.gov/pubmed/29473904 http://dx.doi.org/10.3390/ijms19020634 |