Non-Native Conformational Isomers of the Catalytic Domain of PCSK9 Induce an Immune Response, Reduce Lipids and Increase LDL Receptor Levels

PCSK9 (Proprotein convertase subtilisin/kexin type 9) increases plasma cholesterol levels by promoting LDL receptor degradation. Current antibody inhibitors block the interaction between PCSK9 and LDL receptors, significantly decrease plasma cholesterol levels, and provide beneficial clinical outcom...

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Detalles Bibliográficos
Autores principales: Jiang, Chuantao, Nischal, Hersharan, Sun, Hua, Li, Li, Cao, Ying, Wei, Peng, Chang, Jui-Yoa, Teng, Ba-Bie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855862/
https://www.ncbi.nlm.nih.gov/pubmed/29495280
http://dx.doi.org/10.3390/ijms19020640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855862/
https://www.ncbi.nlm.nih.gov/pubmed/29495280
http://dx.doi.org/10.3390/ijms19020640

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