A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases

Polyglutamine (polyQ) diseases are a class of progressive neurodegenerative disorders characterized by the expression of both expanded CAG RNA and misfolded polyQ protein. We previously reported that the direct interaction between expanded CAG RNA and nucleolar protein nucleolin (NCL) impedes prerib...

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Detalles Bibliográficos
Autores principales: Zhang, Qian, Chen, Zhefan Stephen, An, Ying, Liu, Haizhen, Hou, Yonghui, Li, Wen, Lau, Kwok-Fai, Koon, Alex Chun, Ngo, Jacky Chi Ki, Chan, Ho Yin Edwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855950/
https://www.ncbi.nlm.nih.gov/pubmed/29295891
http://dx.doi.org/10.1261/rna.062703.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855950/
https://www.ncbi.nlm.nih.gov/pubmed/29295891
http://dx.doi.org/10.1261/rna.062703.117

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