Allele-specific SHAPE-MaP assessment of the effects of somatic variation and protein binding on mRNA structure

The impact of inherited and somatic mutations on messenger RNA (mRNA) structure remains poorly understood. Recent technological advances that leverage next-generation sequencing to obtain experimental structure data, such as SHAPE-MaP, can reveal structural effects of mutations, especially when thes...

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Detalles Bibliográficos
Autores principales: Lackey, Lela, Coria, Aaztli, Woods, Chanin, McArthur, Evonne, Laederach, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855952/
https://www.ncbi.nlm.nih.gov/pubmed/29317542
http://dx.doi.org/10.1261/rna.064469.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855952/
https://www.ncbi.nlm.nih.gov/pubmed/29317542
http://dx.doi.org/10.1261/rna.064469.117

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