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Allele-specific SHAPE-MaP assessment of the effects of somatic variation and protein binding on mRNA structure
The impact of inherited and somatic mutations on messenger RNA (mRNA) structure remains poorly understood. Recent technological advances that leverage next-generation sequencing to obtain experimental structure data, such as SHAPE-MaP, can reveal structural effects of mutations, especially when thes...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855952/ https://www.ncbi.nlm.nih.gov/pubmed/29317542 http://dx.doi.org/10.1261/rna.064469.117 |