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Blockade of TGF-β/Smad signaling by the small compound HPH-15 ameliorates experimental skin fibrosis
BACKGROUND: Transforming growth factor-β (TGF-β)/Smad signaling is well known to play a critical role in the pathogenesis of systemic sclerosis (SSc). We previously developed an artificial molecule, the histidine-pyridine-histidine ligand derivative HPH-15, which may have an antifibrotic effect. The...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855969/ https://www.ncbi.nlm.nih.gov/pubmed/29544542 http://dx.doi.org/10.1186/s13075-018-1534-y |