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Blockade of TGF-β/Smad signaling by the small compound HPH-15 ameliorates experimental skin fibrosis

BACKGROUND: Transforming growth factor-β (TGF-β)/Smad signaling is well known to play a critical role in the pathogenesis of systemic sclerosis (SSc). We previously developed an artificial molecule, the histidine-pyridine-histidine ligand derivative HPH-15, which may have an antifibrotic effect. The...

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Detalles Bibliográficos
Autores principales:	Luong, Vu Huy, Chino, Takenao, Oyama, Noritaka, Matsushita, Takashi, Sasaki, Yoko, Ogura, Dai, Niwa, Shin-ichiro, Biswas, Tanima, Hamasaki, Akiyuki, Fujita, Mikako, Okamoto, Yoshinari, Otsuka, Masami, Ihn, Hironobu, Hasegawa, Minoru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855969/ https://www.ncbi.nlm.nih.gov/pubmed/29544542 http://dx.doi.org/10.1186/s13075-018-1534-y

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