Cargando…

Mice with miR-146a deficiency develop severe gouty arthritis via dysregulation of TRAF 6, IRAK 1 and NALP3 inflammasome

BACKGROUND: MicroRNAs (miRNAs) serve as important regulators of inflammatory and immune responses and are implicated in several immune disorders including gouty arthritis. The expression of miR-146a is upregulated in the peripheral blood mononuclear cells of patients with inter-critical gout when co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Quan-Bo, Qing, Yu-Feng, Yin, Cong-Cong, Zhou, Li, Liu, Xian-shuang, Mi, Qing-Sheng, Zhou, Jing-Guo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855987/ https://www.ncbi.nlm.nih.gov/pubmed/29544526 http://dx.doi.org/10.1186/s13075-018-1546-7

Ejemplares similares

Simiaosan alleviates the symptoms of gouty arthritis via the NALP3/IL-1β pathway
por: Zhang, Xianzhen, et al.
Publicado: (2021)

MicroRNA-146a Contributes to SCI Recovery via Regulating TRAF6 and IRAK1 Expression
por: Wei, Jinsong, et al.
Publicado: (2016)

miR-146a Attenuates Sepsis-Induced Myocardial Dysfunction by Suppressing IRAK1 and TRAF6 via Targeting ErbB4 Expression
por: An, Rui, et al.
Publicado: (2018)

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
por: Lamkanfi, Mohamed, et al.
Publicado: (2009)

Ricin Toxin Activates the NALP3 Inflammasome
por: Lindauer, Meghan, et al.
Publicado: (2010)

Influence of intervention treatment by “heat-clearing and diuresis-promoting” prescription on NALP3, an inflammatory factor in acute gouty arthritis
por: Yu, Jun, et al.
Publicado: (2022)

miR-146a Ameliorates Liver Ischemia/Reperfusion Injury by Suppressing IRAK1 and TRAF6
por: Jiang, Weiwei, et al.
Publicado: (2014)

MiR-146a Ameliorates Hemoglobin-Induced Microglial Inflammatory Response via TLR4/IRAK1/TRAF6 Associated Pathways
por: Liu, Guang-Jie, et al.
Publicado: (2020)

Correction: miR-146a Ameliorates Liver Ischemia/Reperfusion Injury by Suppressing IRAK1 and TRAF6
por: Jiang, Weiwei, et al.
Publicado: (2023)

miR-146a Enhances the Oncogenicity of Oral Carcinoma by Concomitant Targeting of the IRAK1, TRAF6 and NUMB Genes
por: Hung, Pei-Shi, et al.
Publicado: (2013)

Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity
por: Bednash, Joseph S., et al.
Publicado: (2017)

The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation
por: Shi, Fushan, et al.
Publicado: (2012)

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal
por: Dostert, Catherine, et al.
Publicado: (2009)

Rhein attenuates inflammation through inhibition of NF-κB and NALP3 inflammasome in vivo and in vitro
por: Ge, Hui, et al.
Publicado: (2017)

MicroRNA-146a Represses Mycobacteria-Induced Inflammatory Response and Facilitates Bacterial Replication via Targeting IRAK-1 and TRAF-6
por: Li, Shuo, et al.
Publicado: (2013)

The NALP3/Cryopyrin-Inflammasome Complex is Expressed in LPS-Induced Ocular Inflammation
por: González-Benítez, José F., et al.
Publicado: (2008)

Inflammasome-Independent NALP3 Contributes to High-Salt Induced Endothelial Dysfunction
por: Fu, Hui, et al.
Publicado: (2018)

NALP3-Inflammasome-Related Gene Polymorphisms in Patients with Prehypertension and Coronary Atherosclerosis
por: Zhao, Xin, et al.
Publicado: (2016)

MicroRNA-146a negatively regulates inflammation via the IRAK1/TRAF6/NF-κB signaling pathway in dry eye
por: Han, Ruifang, et al.
Publicado: (2023)

Common Genetic Variations in the NALP3 Inflammasome Are Associated with Delayed Apoptosis of Human Neutrophils
por: Blomgran, Robert, et al.
Publicado: (2012)

The NALP3/NLRP3 Inflammasome Instigates Obesity-Induced Autoinflammation and Insulin Resistance
por: Vandanmagsar, Bolormaa, et al.
Publicado: (2011)

Mechanisims of asthma and allergic disease – 1081. Resolvin inhibits the cryopyrin/nalp3 inflammasome
por: Ruan, Cox, et al.
Publicado: (2013)

Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia/Reperfusion in Mice
por: Zhang, Nan, et al.
Publicado: (2014)

Expression of dectin-1 and enhanced activation of NALP3 inflammasome are associated with resistance to paracoccidioidomycosis
por: Feriotti, Claudia, et al.
Publicado: (2015)

AEG-1 aggravates inflammation via promoting NALP3 inflammasome formation in murine endometriosis lesions
por: Zhao, Juan, et al.
Publicado: (2019)

YTHDC1-Modified m6A Methylation of Hsa_circ_0102678 Promotes Keratinocyte Inflammation Induced by Cutibacterium acnes Biofilm through Regulating miR-146a/TRAF6 and IRAK1 Axis
por: Zhou, Meng, et al.
Publicado: (2023)

Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes
por: Fan, Weimin, et al.
Publicado: (2021)

MicroRNA-146a-5p alleviates lipopolysaccharide-induced NLRP3 inflammasome injury and pro-inflammatory cytokine production via the regulation of TRAF6 and IRAK1 in human umbilical vein endothelial cells (HUVECs)
por: Hou, Jingyuan, et al.
Publicado: (2021)

Chronic constriction injury-induced microRNA-146a-5p alleviates neuropathic pain through suppression of IRAK1/TRAF6 signaling pathway
por: Wang, Zhiyao, et al.
Publicado: (2018)

Effects of acupuncture on the miR-146a-mediated IRAK1/TRAF6/NF-κB signaling pathway in rats with sarcopenia induced by D-galactose
por: Jin, Jing, et al.
Publicado: (2023)

Suppressive Effect of Huzhentongfeng on Experimental Gouty Arthritis: An In Vivo and In Vitro Study
por: Wu, Zi-cong, et al.
Publicado: (2019)

Association of microRNA-146a and their target gene IRAK-1 polymorphism with enthesitis related arthritis category of juvenile idiopathic arthritis
por: Singh, Sushma, et al.
Publicado: (2014)

Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation
por: Lendermon, Elizabeth A., et al.
Publicado: (2017)

CASPorter: A Novel Inducible Human CASP1/NALP3/ASC Inflammasome Biosensor
por: Zou, Chan, et al.
Publicado: (2022)

Association of NLRP3 polymorphisms with susceptibility to primary gouty arthritis in a Chinese Han population
por: Zhang, Quan-Bo, et al.
Publicado: (2017)

BAP31 regulates IRAK1-dependent neuroinflammation in microglia
por: Liu, Xia, et al.
Publicado: (2019)

Effects of Gentiopicroside on activation of NLRP3 inflammasome in acute gouty arthritis mice induced by MSU
por: He, Menglin, et al.
Publicado: (2021)

LncRNA MALAT1 promotes high glucose-induced inflammatory response of microglial cells via provoking MyD88/IRAK1/TRAF6 signaling
por: Wang, Li-Qing, et al.
Publicado: (2018)

Sertoli cells have a functional NALP3 inflammasome that can modulate autophagy and cytokine production
por: Hayrabedyan, Soren, et al.
Publicado: (2016)

The Overexpression of NALP3 Inflammasome in Knee Osteoarthritis Is Associated with Synovial Membrane Prolidase and NADPH Oxidase 2
por: Clavijo-Cornejo, Denise, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_95vs9i7ao4blfied9d9ila3gsd