Apoptosome formation upon overexpression of native and truncated Apaf-1 in cell-free and cell-based systems

Apaf-1 is a cytosolic multi-domain protein in the apoptosis regulatory network. When cytochrome c releases from mitochondria; it binds to WD-40 repeats of Apaf-1 molecule and induces oligomerization of Apaf-1. Here in, a split luciferase assay was used to compare apoptosome formation in cell-free an...

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Detalles Bibliográficos
Autores principales: Noori, Ali Reza, Hosseini, Elaheh Sadat, Nikkhah, Maryam, Hosseinkhani, Saman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856089/
https://www.ncbi.nlm.nih.gov/pubmed/29410086
http://dx.doi.org/10.1016/j.abb.2018.01.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856089/
https://www.ncbi.nlm.nih.gov/pubmed/29410086
http://dx.doi.org/10.1016/j.abb.2018.01.017

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