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Apoptosome formation upon overexpression of native and truncated Apaf-1 in cell-free and cell-based systems
Apaf-1 is a cytosolic multi-domain protein in the apoptosis regulatory network. When cytochrome c releases from mitochondria; it binds to WD-40 repeats of Apaf-1 molecule and induces oligomerization of Apaf-1. Here in, a split luciferase assay was used to compare apoptosome formation in cell-free an...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856089/ https://www.ncbi.nlm.nih.gov/pubmed/29410086 http://dx.doi.org/10.1016/j.abb.2018.01.017 |