Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

BACKGROUND: We have evaluated the efficacy of targeting the toxic, oligomeric form of tau protein by passive immunotherapy in a mouse model of synucleinopathy. Parkinson’s disease and Lewy body dementia are two of the most common neurodegenerative disorders and are primarily characterized by the acc...

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Detalles Bibliográficos
Autores principales: Gerson, Julia E., Farmer, Kathleen M., Henson, Natalie, Castillo-Carranza, Diana L., Carretero Murillo, Mariana, Sengupta, Urmi, Barrett, Alan, Kayed, Rakez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856311/
https://www.ncbi.nlm.nih.gov/pubmed/29544548
http://dx.doi.org/10.1186/s13024-018-0245-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856311/
https://www.ncbi.nlm.nih.gov/pubmed/29544548
http://dx.doi.org/10.1186/s13024-018-0245-9

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