Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources of biases affecting DNA methylation data

BACKGROUND: Whole-genome bisulfite sequencing (WGBS) is becoming an increasingly accessible technique, used widely for both fundamental and disease-oriented research. Library preparation methods benefit from a variety of available kits, polymerases and bisulfite conversion protocols. Although some s...

Descripción completa

Detalles Bibliográficos
Autores principales: Olova, Nelly, Krueger, Felix, Andrews, Simon, Oxley, David, Berrens, Rebecca V., Branco, Miguel R., Reik, Wolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856372/
https://www.ncbi.nlm.nih.gov/pubmed/29544553
http://dx.doi.org/10.1186/s13059-018-1408-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856372/
https://www.ncbi.nlm.nih.gov/pubmed/29544553
http://dx.doi.org/10.1186/s13059-018-1408-2

Ejemplares similares