Neonatal hyperglycemia induces CXCL10/CXCR3 signaling and microglial activation and impairs long-term synaptogenesis in the hippocampus and alters behavior in rats

BACKGROUND: Hyperglycemia is common in extremely low gestational age newborns (ELGAN) and is associated with increased mortality and morbidity, including abnormal neurodevelopment. Hippocampus-mediated cognitive deficits are common in this population, but the specific effects of hyperglycemia on the...

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Detalles Bibliográficos
Autores principales: Satrom, Katherine M., Ennis, Kathleen, Sweis, Brian M., Matveeva, Tatyana M., Chen, Jun, Hanson, Leif, Maheshwari, Akhil, Rao, Raghavendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856387/
https://www.ncbi.nlm.nih.gov/pubmed/29544513
http://dx.doi.org/10.1186/s12974-018-1121-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856387/
https://www.ncbi.nlm.nih.gov/pubmed/29544513
http://dx.doi.org/10.1186/s12974-018-1121-9

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