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Neonatal hyperglycemia induces CXCL10/CXCR3 signaling and microglial activation and impairs long-term synaptogenesis in the hippocampus and alters behavior in rats
BACKGROUND: Hyperglycemia is common in extremely low gestational age newborns (ELGAN) and is associated with increased mortality and morbidity, including abnormal neurodevelopment. Hippocampus-mediated cognitive deficits are common in this population, but the specific effects of hyperglycemia on the...
Autores principales: | Satrom, Katherine M., Ennis, Kathleen, Sweis, Brian M., Matveeva, Tatyana M., Chen, Jun, Hanson, Leif, Maheshwari, Akhil, Rao, Raghavendra |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856387/ https://www.ncbi.nlm.nih.gov/pubmed/29544513 http://dx.doi.org/10.1186/s12974-018-1121-9 |
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