Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase

The interactions between proteins and biological membranes are important for drug development, but remain notoriously refractory to structural investigation. We combine non-denaturing mass spectrometry (MS) with molecular dynamics (MD) simulations to unravel the connections among co-factor, lipid, a...

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Detalles Bibliográficos
Autores principales: Costeira-Paulo, Joana, Gault, Joseph, Popova, Gergana, Ladds, Marcus J.G.W., van Leeuwen, Ingeborg M.M., Sarr, Médoune, Olsson, Anders, Lane, David P., Laín, Sonia, Marklund, Erik G., Landreh, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856493/
https://www.ncbi.nlm.nih.gov/pubmed/29358052
http://dx.doi.org/10.1016/j.chembiol.2017.12.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856493/
https://www.ncbi.nlm.nih.gov/pubmed/29358052
http://dx.doi.org/10.1016/j.chembiol.2017.12.012

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