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Dose-dependent effects on rat liver miRNAs 200a/b and 429: potential early biomarkers of liver carcinogenesis

An increased incidence of liver tumours in the long term rodent bioassay is not an uncommon finding, invariably as a result of a non-genotoxic mode of action. Non-genotoxic liver carcinogenesis has been found to involve activation of certain nuclear hormone receptors (NHR) including the constitutive...

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Detalles Bibliográficos
Autores principales: Plummer, S.M., Wright, J., Currie, R.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856664/
https://www.ncbi.nlm.nih.gov/pubmed/29556478
http://dx.doi.org/10.1016/j.toxrep.2018.02.004