Cargando…
Physiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing
High protein feeding improves glucose homeostasis in rodents and humans with diabetes, but the mechanisms that underlie this improvement remain elusive. Here we show that acute administration of casein hydrolysate directly into the upper small intestine increases glucose tolerance and inhibits gluco...
Autores principales: | Dranse, Helen J., Waise, T. M. Zaved, Hamr, Sophie C., Bauer, Paige V., Abraham, Mona A., Rasmussen, Brittany A., Lam, Tony K. T. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856761/ https://www.ncbi.nlm.nih.gov/pubmed/29549253 http://dx.doi.org/10.1038/s41467-018-03490-8 |
Ejemplares similares
-
Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport
por: Beale, John H., et al.
Publicado: (2015) -
Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes
por: Killer, Maxime, et al.
Publicado: (2021) -
Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production
por: Waise, T. M. Zaved, et al.
Publicado: (2019) -
Regulation profile of the intestinal peptide transporter 1 (PepT1)
por: Wang, Chun-Yang, et al.
Publicado: (2017) -
Critical Role of PepT1 in Promoting Colitis-Associated Cancer and Therapeutic Benefits of the Anti-inflammatory PepT1-Mediated Tripeptide KPV in a Murine Model
por: Viennois, Emilie, et al.
Publicado: (2016)