Sites associated with Kalydeco binding on human Cystic Fibrosis Transmembrane Conductance Regulator revealed by Hydrogen/Deuterium Exchange

Cystic Fibrosis (CF) is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). Mutations associated with CF cause loss-of-function in CFTR leading to salt imbalance in epithelial tissues. Kalydeco (also called VX-770 or ivacaftor) was approved for CF treatment in 2012...

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Detalles Bibliográficos
Autores principales: Byrnes, Laura J., Xu, Yingrong, Qiu, Xiayang, Hall, Justin D., West, Graham M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856801/
https://www.ncbi.nlm.nih.gov/pubmed/29549268
http://dx.doi.org/10.1038/s41598-018-22959-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856801/
https://www.ncbi.nlm.nih.gov/pubmed/29549268
http://dx.doi.org/10.1038/s41598-018-22959-6

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