Imaging of conditional gene silencing in vivo using a bioluminescence-based method with thermo-inducible microRNAs

RNA interference (RNAi)-based gene therapy has great potential in cancer and infectious disease treatment to correct abnormal up-regulation of gene expression. We show a new original method uses synthetic microRNAs combined with a thermo-inducible promoter to reduce specific gene expression. The tar...

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Detalles Bibliográficos
Autores principales: Pinel, Karine, Genevois, Coralie, Debeissat, Christelle, Couillaud, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856835/
https://www.ncbi.nlm.nih.gov/pubmed/29549271
http://dx.doi.org/10.1038/s41598-018-22932-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856835/
https://www.ncbi.nlm.nih.gov/pubmed/29549271
http://dx.doi.org/10.1038/s41598-018-22932-3

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