Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and availability of integrase inhibitors in Cape Town, South Africa

HIV-Integrase (IN) has proven to be a viable target for highly specific HIV-1 therapy. We aimed to characterize the HIV-1 IN gene in a South African context and identify resistance-associated mutations (RAMs) against available first and second generation Integrase strand-transfer inhibitors (InSTIs)...

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Detalles Bibliográficos
Autores principales: Brado, Dominik, Obasa, Adetayo Emmanuel, Ikomey, George Mondinde, Cloete, Ruben, Singh, Kamalendra, Engelbrecht, Susan, Neogi, Ujjwal, Jacobs, Graeme Brendon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856838/
https://www.ncbi.nlm.nih.gov/pubmed/29549274
http://dx.doi.org/10.1038/s41598-018-22914-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856838/
https://www.ncbi.nlm.nih.gov/pubmed/29549274
http://dx.doi.org/10.1038/s41598-018-22914-5

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