Explaining Ethnic Variability of Transporter Substrate Pharmacokinetics in Healthy Asian and Caucasian Subjects with Allele Frequencies of OATP1B1 and BCRP: A Mechanistic Modeling Analysis

BACKGROUND: Ethnic variability in the pharmacokinetics of organic anion transporting polypeptide (OATP) 1B1 substrates has been observed, but its basis is unclear. A previous study hypothesizes that, without applying an intrinsic ethnic variability in transporter activity, allele frequencies of tran...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Rui, Barton, Hugh A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856892/
https://www.ncbi.nlm.nih.gov/pubmed/28653144
http://dx.doi.org/10.1007/s40262-017-0568-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856892/
https://www.ncbi.nlm.nih.gov/pubmed/28653144
http://dx.doi.org/10.1007/s40262-017-0568-7

Ejemplares similares