Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes

In Huntington’s disease (HD), expansion of CAG codons within the huntingtin gene (HTT) leads to the aberrant formation of protein aggregates and the differential degeneration of striatal medium spiny neurons (MSNs). Modeling HD using patient-specific MSNs has been challenging, as neurons differentia...

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Detalles Bibliográficos
Autores principales: Victor, Matheus B., Richner, Michelle, Olsen, Hannah E., Lee, Seong Won, Monteys, Alejandro M., Ma, Chunyu, Huh, Christine J., Zhang, Bo, Davidson, Beverly L., Yang, X. William, Yoo, Andrew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857213/
https://www.ncbi.nlm.nih.gov/pubmed/29403030
http://dx.doi.org/10.1038/s41593-018-0075-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857213/
https://www.ncbi.nlm.nih.gov/pubmed/29403030
http://dx.doi.org/10.1038/s41593-018-0075-7

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