Cargando…

Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes

In Huntington’s disease (HD), expansion of CAG codons within the huntingtin gene (HTT) leads to the aberrant formation of protein aggregates and the differential degeneration of striatal medium spiny neurons (MSNs). Modeling HD using patient-specific MSNs has been challenging, as neurons differentia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Victor, Matheus B., Richner, Michelle, Olsen, Hannah E., Lee, Seong Won, Monteys, Alejandro M., Ma, Chunyu, Huh, Christine J., Zhang, Bo, Davidson, Beverly L., Yang, X. William, Yoo, Andrew S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857213/ https://www.ncbi.nlm.nih.gov/pubmed/29403030 http://dx.doi.org/10.1038/s41593-018-0075-7

Ejemplares similares

BACHD Mice Recapitulate the Striatal Parvalbuminergic Interneuron Loss Found in Huntington’s Disease
por: Rallapalle, Vyshnavi, et al.
Publicado: (2021)

PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease
por: Morozko, Eva L., et al.
Publicado: (2021)

Huntington’s Disease and Striatal Signaling
por: Roze, Emmanuel, et al.
Publicado: (2011)

Cardiac mTORC1 Dysregulation Impacts Stress Adaptation and Survival in Huntington’s Disease
por: Child, Daniel D., et al.
Publicado: (2018)

Cortical and Striatal Circuits in Huntington’s Disease
por: Blumenstock, Sonja, et al.
Publicado: (2020)

Striatal network modeling in Huntington’s Disease
por: Ponzi, Adam, et al.
Publicado: (2020)

Proteostasis in striatal cells and selective neurodegeneration in Huntington’s disease
por: Margulis, Julia, et al.
Publicado: (2014)

The mechanism of degeneration of striatal neuronal subtypes in Huntington disease
por: Rikani, Azadeh A., et al.
Publicado: (2014)

Striatal Vulnerability in Huntington’s Disease: Neuroprotection Versus Neurotoxicity
por: Morigaki, Ryoma, et al.
Publicado: (2017)

Striatal Network Models of Huntington's Disease Dysfunction Phenotypes
por: Zheng, Pengsheng, et al.
Publicado: (2017)

Striatal parvalbuminergic neurons are lost in Huntington's disease: implications for dystonia
por: Reiner, Anton, et al.
Publicado: (2013)

Striatal Interneurons in Transgenic Nonhuman Primate Model of Huntington’s Disease
por: Lallani, Shoeb B., et al.
Publicado: (2019)

Dual tasking impairments are associated with striatal pathology in Huntington’s disease
por: Lo, Johnny, et al.
Publicado: (2020)

Human striatal organoids derived from pluripotent stem cells recapitulate striatal development and compartments
por: Chen, Xinyu, et al.
Publicado: (2022)

Striatal Pre-Enkephalin Overexpression Improves Huntington’s Disease Symptoms in the R6/2 Mouse Model of Huntington’s Disease
por: Bissonnette, Stéphanie, et al.
Publicado: (2013)

Fetal striatal grafting slows motor and cognitive decline of Huntington's disease
por: Paganini, Marco, et al.
Publicado: (2014)

VGF and striatal cell damage in in vitro and in vivo models of Huntington’s disease
por: Noda, Yasuhiro, et al.
Publicado: (2015)

Preserving cortico-striatal function: deep brain stimulation in Huntington’s disease
por: Nagel, Sean J., et al.
Publicado: (2015)

Functional connectivity modeling of consistent cortico-striatal degeneration in Huntington's disease
por: Dogan, Imis, et al.
Publicado: (2015)

Striatal Neurodegeneration that Mimics Huntington’s Disease Modifies GABA-induced Currents
por: Flores-Hernández, Jorge, et al.
Publicado: (2018)

Altered enhancer transcription underlies Huntington’s disease striatal transcriptional signature
por: Le Gras, Stéphanie, et al.
Publicado: (2017)

Rate of torque development and striatal shape in individuals with prodromal Huntington's disease
por: Cruickshank, Travis, et al.
Publicado: (2020)

Diminished LC3-Associated Phagocytosis by Huntington’s Disease Striatal Astrocytes
por: Wakida, Nicole M., et al.
Publicado: (2022)

Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington’s disease
por: Matsushima, Ayano, et al.
Publicado: (2023)

Abnormal Brain Development in Huntington’ Disease Is Recapitulated in the zQ175 Knock-In Mouse Model
por: Zhang, Chuangchuang, et al.
Publicado: (2020)

A Role for Oxidized DNA Precursors in Huntington's Disease–Like Striatal Neurodegeneration
por: De Luca, Gabriele, et al.
Publicado: (2008)

Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease
por: Ju, Tz-Chuen, et al.
Publicado: (2011)

Environment-dependent striatal gene expression in the BACHD rat model for Huntington disease
por: Novati, Arianna, et al.
Publicado: (2018)

White matter cortico-striatal tracts predict apathy subtypes in Huntington's disease
por: De Paepe, Audrey E., et al.
Publicado: (2019)

Angiotensins and Huntington’s Disease: A Study on Immortalized Progenitor Striatal Cell Lines
por: De Mello, Walmor C., et al.
Publicado: (2017)

Changes in striatal activity and functional connectivity in a mouse model of Huntington's disease
por: Cabanas, Magali, et al.
Publicado: (2017)

Reduced Fractalkine Levels Lead to Striatal Synaptic Plasticity Deficits in Huntington’s Disease
por: Kim, Anya, et al.
Publicado: (2020)

Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington’s disease
por: Fernández-García, S., et al.
Publicado: (2020)

Impaired XK recycling for importing manganese underlies striatal vulnerability in Huntington's disease
por: Chhetri, Gaurav, et al.
Publicado: (2022)

Striatal Induction and Spread of the Huntington’s Disease Protein: A Novel Rhes Route
por: Subramaniam, Srinivasa
Publicado: (2022)

Temporal Phenotypic Changes in Huntington’s Disease Models for Preclinical Studies
por: St-Cyr, Sophie, et al.
Publicado: (2022)

Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease
por: Gu, Xiaofeng, et al.
Publicado: (2007)

Insight Into the Emerging Role of Striatal Neurotransmitters in the Pathophysiology of Parkinson’s Disease and Huntington’s Disease: A Review
por: Jamwal, Sumit, et al.
Publicado: (2019)

Intraparenchymal Striatal Transplants Required for Maintenance of Behavioral Recovery in an Animal Model of Huntington's Disease
por: Sanberg, Paul R., et al.
Publicado: (1989)

Altered Balance of Activity in the Striatal Direct and Indirect Pathways in Mouse Models of Huntington's Disease
por: André, Véronique M., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_i4ipf3qvhfq8f7ac9hn0v45aq7